Dissemination & Outreach

One of EpilipidNET’s main goals is to contribute to the wider public understanding of the importance of different kinds of lipids and their measurement in everyday life. To achieve this goal, EpilipidNET develops and disseminates content explaining the project’s scope of action and results.

Videos about EpiLipidNET

Welcome to EpiLipidNET!

Newsletters

Newsletters about activities of the members of EpiLipidNET:

  • July 2023 – In this edition we are bringing you news from several meetings and conferences in the first half of 2023 where EpiLipidNET members participated or organized sessions. Read more
     EpiLipidNET Action and we finally had a chance to meet face to face! Read moreEpilipidNET Newsletter 2023 July
  • December 2022 – It has been a wonderful and very fruitful 2nd year for the EpiLipidNET Action and we finally had a chance to meet face to face! Read more
  • September 2022 – Our GP2 is almost over and it has been a quite challenging, but a very good year for EpiLipidNET COST Action.  Read more
  • June 2021 – The next general Action EpiLipidNET meeting will take place (on-line via zoom; free of charge to everyone who is interested) on 23 – 24th of September! Read more

Talking about epilipids…

Podcast, press-release, and others by the members of the COST Action:

  • Medical News about EpiLipidNET participation in COST Connect: A platform for collaboration and progress in cancer research. “Amazing to see how many ideas come up if people with different background simply sit around one table and discuss possible solutions for a given problem. Diversity of expertise is the key!” Dr Maria Fedorova, vice-Chair of EpiLipidNET

  • Networking with Astromad.eu.We create synergies with researchers, projects and entities because collaborating and sharing knowledge with others is essential for scientific progress

  • Webcast presentation for the European Society for Dermatological Research by our  colleague Dr Florian Gruber (EpilipidNET WG4 leader), expert in skin lipidomics

  • A LIPID MAPS® Podcast hosted by Matthew Conroy who’s joined by Professor Laura Goracci (EpiLipidNET WG2 leader) to discuss EpiLipids. Available in Spotify, YouTube, Apple Podcasts

Publications

Publications written by the members of the COST Action:

  1. Neves B, Pérez-Sala D, Ferreira HB, Guerra IMS, Moreira ASP, Domingues P, Domingues MR, Melo T. Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids. Prog Lipid Res. 2022 Jul;87:101176. doi: 10.1016/j.plipres.2022.101176 (Portugal-Spain)
  2. Conde T, Lopes D, Łuczaj W, Neves B, Pinto B, Maurício T, Domingues P, Skrzydlewska E, Domingues MR. Algal Lipids as Modulators of Skin Disease: A Critical Review. Metabolites. 2022 Jan 20;12(2):96. doi: 10.3390/metabo12020096 (Poland-Portugal)
  3. Sochorová M, Vávrová K, Fedorova M, Ni Z, Slenter D, Kutmon M, Willighagen E, Letsiou S, Töröcsik D, Marchetti-Deschmann M, Zoratto S, Kremslehner C,Gruber F. Research Techniques Made Simple: Lipidomic Analysis in Skin Research. Journal of Investigative Dermatology. 2022 Jan 1; 142(1): 4-11.e1. doi: 10.1016/j.jid.2021.09.017 (Austria-Czech Republic-Germany-Hungary-Netherlands)
  4. Sohrabi Y, Schwarz D, Reinecke H. LDL-C augments whereas HDL-C prevents inflammatory innate immune memory. Trends in Molecular Medicine. 2022 Jan; 28(1): 1-4. doi: 10.1016/j.molmed.2021.11.003 (Czech Republic-Germany)
  5. Rey F, Greenacre M, Silva Neto GM, Bueno-Pardo J, Domingues MR, Calado R. Fatty acid ratio analysis identifies changes in competent meroplanktonic larvae sampled over different supply events. Mar Environ Res. 2022 Jan;173:105517. doi: 10.1016/j.marenvres.2021.105517 (Portugal-Spain)
  6. Gladine C, Fedorova M. The clinical translation of eicosanoids and other oxylipins, although challenging, should be actively pursued. J Mass Spectrom Adv Clin Lab. 2021 Aug 25;21:27-30. doi: 10.1016/j.jmsacl.2021.08.003 (France-Germany)
  7. Atalay S, Gęgotek A, Domingues P, Skrzydlewska E. Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network. Redox Biol. 2021 Oct;46:102074. doi: 10.1016/j.redox.2021.102074 (Poland-Portugal)
  8. Conde TA, Zabetakis I, Tsoupras A, Medina I, Costa M, Silva J, Neves B, Domingues P, Domingues MR. Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review. Int J Mol Sci. 2021 Sep 11;22(18):9825. doi: 10.3390/ijms22189825 (Ireland-Portugal)
  9. Smolič T, Tavčar P, Horvat A, Černe U, Halužan Vasle A, Tratnjek L, Kreft ME, Scholz N, Matis M, Petan T, Zorec R, Vardjan N. Astrocytes in stress accumulate lipid droplets. Glia. 2021 Jun;69(6):1540-1562. doi: 10.1002/glia.23978 (Germany-Slovenia)
  10. Łuczaj W, Jastrząb A, do Rosário Domingues M, Domingues P, Skrzydlewska E. Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol. Int J Mol Sci. 2021 Aug 13;22(16):8700. doi: 10.3390/ijms22168700 (Poland-Portugal)
  11. Łuczaj W, Domingues MDR, Domingues P, Skrzydlewska E. Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol. Antioxidants (Basel). 2020 Nov 25;9(12):1178. doi: 10.3390/antiox9121178 (Poland-Portugal)
  12. Łuczaj W, Dobrzyńska I, Wroński A, Domingues MR, Domingues P, Skrzydlewska E. Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients. Int J Mol Sci. 2020 Sep 9;21(18):6592. doi: 10.3390/ijms21186592 (Poland-Portugal)
  13. McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O’Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K. Introducing the Lipidomics Minimal Reporting Checklist. Nat Metab. 2022 Sep;4(9):1086-1088. doi: 10.1038/s42255-022-00628-3 (United Kingdom-Germany)
  14. Köfeler HC, Eichmann TO, Ahrends R, Bowden JA, Danne-Rasche N, Dennis EA, Fedorova M, Griffiths WJ, Han X, Hartler J, Holčapek M, Jirásko R, Koelmel JP, Ejsing CS, Liebisch G, Ni Z, O’Donnell VB, Quehenberger O, Schwudke D, Shevchenko A, Wakelam MJO, Wenk MR, Wolrab D, Ekroos K. Quality control requirements for the correct annotation of lipidomics data. Nat Commun. 2021 Aug 6;12(1):4771. doi: 10.1038/s41467-021-24984-y (United Kingdom-Germany)
  15. Oskolkova OV, Hodzic A, Karki P, Gesslbauer B, Ke Y, Hofer DC, Bogner-Strauss JG, Galano JM, Oger C, Birukova A, Durand T, Birukov K, Bochkov V. Oxidized phospholipids on alkyl-amide scaffold demonstrate anti-endotoxin and endothelial barrier-protective properties. Free Radic Biol Med. 2021 Oct;174:264-271. doi: 10.1016/j.freeradbiomed.2021.07.041 (Austria-France)
  16. Liebisch G, Fahy E, Aoki J, Dennis EA, Durand T, Ejsing CS, Fedorova M, Feussner I, Griffiths WJ, Köfeler H, Merrill AH Jr, Murphy RC, O’Donnell VB, Oskolkova O, Subramaniam S, Wakelam MJO, Spener F. Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. J Lipid Res. 2020 Dec;61(12):1539-1555. doi: 10.1194/jlr.S120001025 (Austria-Germany-France-United Kingdom)
  17. Viedma-Poyatos Á, González-Jiménez P, Langlois O, Company-Marín I, Spickett CM, Pérez-Sala D. Protein Lipoxidation: Basic Concepts and Emerging Roles. Antioxidants (Basel). 2021 Feb 16;10(2):295. doi: 10.3390/antiox10020295 (Spain-United Kingdom)
  18. Lairón-Peris M, Routledge SJ, Linney JA, Alonso-Del-Real J, Spickett CM, Pitt AR, Guillamón JM, Barrio E, Goddard AD, Querol A. Lipid Composition Analysis Reveals Mechanisms of Ethanol Tolerance in the Model Yeast Saccharomyces cerevisiae. Appl Environ Microbiol. 2021 May 26;87(12):e0044021. doi: 10.1128/AEM.00440-21 (Spain-United Kingdom)
  19. Káňovičová P, Čermáková P, Kubalová D, Bábelová L, Veselá P, Valachovič M, Zahumenský J, Horváth A, Malínský J, Balážová M. Blocking phosphatidylglycerol degradation in yeast defective in cardiolipin remodeling results in a new model of the Barth syndrome cellular phenotype. J Biol Chem. 2022 Jan;298(1):101462. doi: 10.1016/j.jbc.2021.101462 (Slovakia-Czech Republik)
  20. Žarković N, Orehovec B, Baršić B, Tarle M, Kmet M, Lukšić I, Tatzber F, Wonisch W, Skrzydlewska E, Łuczaj W. Lipidomics Revealed Plasma Phospholipid Profile Differences between Deceased and Recovered COVID-19 Patients. Biomolecules. 2022; 12(10):1488. doi: 10.3390/biom12101488 (Austria-Croatia-Poland)
  21. Žarković N, Łuczaj W, Jarocka-Karpowicz I, Orehovec B, Baršić B, Tarle M, Kmet M, Lukšić I, Biernacki M, Skrzydlewska E. Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital. Int J Mol Sci. 2022; 23(19):11810. doi: 10.3390/ijms231911810 (Croatia-Poland)
  22. Criscuolo A, Nepachalovich P, Garcia-Del Rio DF, Lange M, Ni Z, Baroni M, Cruciani G, Goracci L, Blüher M, Fedorova M. Analytical and computational workflow for in-depth analysis of oxidized complex lipids in blood plasma. Nat Commun. 2022; 13(1):6547. doi: 10.1038/s41467-022-33225-9 (Germany-Italy)
  23. Ferreira HB, Barros C, Melo T, Paiva A, Domingues MR. Looking in Depth at Oxidized Cholesteryl Esters by LC-MS/MS: Reporting Specific Fragmentation Fingerprints and Isomer Discrimination. J Am Soc Mass Spectrom. 2022; 33(5):793-802. doi: 10.1021/jasms.1c00370 (Portugal)
  24. Ferreira HB, Guerra IMS, Melo T, Rocha H, Moreira ASP, Paiva A, Domingues MR. Dried blood spots in clinical lipidomics: optimization and recent findings. Anal Bioanal Chem. 2022;414(24):7085-7101. doi: 10.1007/s00216-022-04221-1 (Portugal)
  25. Răchieriu C, Eniu DT, Moiş E, Graur F, Socaciu C, Socaciu MA, Hajjar NA. Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS. Biomolecules. 2021; 11(3):417. doi: 10.3390/biom11030417 (Romania)
  26. Homorogan C, Nitusca D, Enatescu V, Schubart P, Moraru C, Socaciu C, Marian C. Untargeted Plasma Metabolomic Profiling in Patients with Major Depressive Disorder Using Ultra-High Performance Liquid Chromatography Coupled with Mass Spectrometry. Metabolites. 2021; 11(7):466. doi: 10.3390/metabo11070466 (Romania)
  27. Eniu DT, Chiorean AR, Socaciu AI, Staicu A, Rachieriu C, Goidescu I, Buiga R, Eniu D, Socaciu C, Chira R. Blood and urine biomarkers in invasive ductal breast cancer: Mass spectrometry applied to identify metabolic alterations. Journal of Molecular Structure. 2022; 1247, doi: 10.1016/j.molstruc.2021.131369 (Romania)
  28. Burghelea D, Moisoiu T, Ivan C, Elec A, Munteanu A, Iancu ȘD, Truta A, Kacso TP, Antal O, Socaciu C, Elec FI, Kacso IM. The Use of Machine Learning Algorithms and the Mass Spectrometry Lipidomic Profile of Serum for the Evaluation of Tacrolimus Exposure and Toxicity in Kidney Transplant Recipients. Biomedicines. 2022; 10(5):1157. doi: 10.3390/biomedicines10051157 (Romania)
  29. Nenu I, Stefanescu H, Procopet B, Sparchez Z, Minciuna I, Mocan T, Leucuta D, Morar C, Grigorescu M, Filip GA, Socaciu C. Navigating through the Lipid Metabolism Maze: Diagnosis and Prognosis Metabolites of Hepatocellular Carcinoma versus Compensated Cirrhosis. J Clin Med. 2022; 11(5):1292. doi: 10.3390/jcm11051292 (Romania)
  30. Fischer P, Pandrea S, Grigoras C, Stefanescu H, Farcau O, Tefas C, Socaciu C, Procopet B, Ionescu D. Blood Metabolomic Signatures to Identify Bacterial Infection in Patients with Decompensated Cirrhosis. J Gastrointestin Liver Dis. 2022; 31(1):40-47. doi: 10.15403/jgld-4034 (Romania)
  31. Socaciu C, Dulf F, Socaci S, Ranga F, Bunea A, Fetea F, Pintea A. Phytochemical Profile of Eight Categories of Functional Edible Oils: A Metabolomic Approach Based on Chromatography Coupled with Mass Spectrometry. Applied Sciences. 2022; 12(4):1933. doi: 10.3390/app12041933 (Romania)
  32. Ismaiel A, Spinu M, Socaciu C, Budisan L, Leucuta DC, Popa SL, Chis BA, Berindan-Neagoe I, Olinic DM, Dumitrascu DL. Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysis. Nutr Diabetes. 2022; 12(1):4. doi: 10.1038/s41387-022-00182-7 (Romania)
  33. Rey F, Melo T, Lopes D, Couto D, Marques F, Domingues MR. Applications of lipidomics in marine organisms: progress, challenges and future perspectives. Mol Omics. 2022; 18(5):357-386. doi: 10.1039/d2mo00012a (Portugal)
  34. Alves E, Rey F, Melo T, Barros MP, Domingues P, Domingues R. Bioprospecting Bioactive Polar Lipids from Olive (Olea europaea cv. Galega vulgar) Fruit Seeds: LC-HR-MS/MS Fingerprinting and Sub-Geographic Comparison. Foods. 2022; 11(7):951. doi: 10.3390/foods11070951 (Portugal)
  35. Gaspar L, Ricardo F, Melo T, Domingues P, Domingues MR, Calado R, Rey F. Lipidomics of common octopus’ (Octopus vulgaris) arm muscle using untargeted high-resolution liquid chromatography-mass spectrometry. Journal of Food Composition and Analysis. 2023; 115, 104871. doi: 10.1016/j.jfca.2022.104871 (Portugal)
  36. Sarmento, M.J., Llorente, A., Petan, T., Khnykin, D., Popa, I., Perkovic, M. N., Konjevod, M., Jaganjac, M. The expanding organelle lipidomes: current knowledge and challenges. Cell. Mol. Life Sci. 2023; 80, 237. doi: 10.1007/s00018-023-04889-3 (Portugal-Norway-Slovenia-France-Croatia)
  37. Ferreira HB, Melo T, Rocha H, Paiva A, Domingues P, Domingues MR. Lipid profile variability in children at different ages measured in dried blood spots. Mol Omics. 2023; 19(3):229-237. doi: 10.1039/d2mo00206j
  38. Kovács D, Camera E, Póliska S, Cavallo A, Maiellaro M, Dull K, Gruber F, Zouboulis C C, Szegedi A, Törócsik D.  Linoleic Acid Induced Changes in SZ95 Sebocytes—Comparison with Palmitic Acid and Arachidonic Acid. Nutrients. 2023; 15, 3315. doi: 10.3390/nu15153315
  39. Tietel Z, Hammann S, Meckelmann SW, Ziv C, Pauling JK, Wölk M, Würf V, Alves E, Neves B, Domingues MR. An overview of food lipids toward food lipidomics. Compr. Rev. Food Sci. Food Saf. 2023; 1–53. doi:10.1111/1541-4337.13225
  40. Bonciarelli S, Neves B, Domingues P, Melo T, Goracci L, Domingues MR. Analysis of Phosphatidylinositol Modifications by Reactive Nitrogen Species Using LC-MS: Coming to Grips with Their Nitroxidative Susceptibility. J. Am. Soc. Mass Spectrom. 2023; 34 (7): 1372-1382. doi:10.1021/jasms.3c00057 (Italy-Portugal)
  41. Jovičić EJ, Janež AP, Eichmann TO, Koren Š, Brglez V, Jordan PM, Gerstmeier J, Lainšček D, Golob-Urbanc A, Jerala R, Lambeau G, Werz O, Zimmermann R, Petan T. Lipid droplets control mitogenic lipid mediator production in human cancer cells. Mol Metab. 2023; 76:101791. doi: 10.1016/j.molmet.2023.101791
  42. Ferreira HB, Melo T, Guerra IMS, Moreira ASP, Laranjeira P, Paiva A, Goracci L, Bonciarelli S, Domingues P, Domingues MR. Whole Blood and Plasma-Based Lipid Profiling Reveals Distinctive Metabolic Changes in Systemic Lupus Erythematosus and Systemic Sclerosis. J Proteome Res. 2023; 22(9):2995-3008. doi: 10.1021/acs.jproteome.3c00321
CA19105 – Pan-European Network in Lipidomics and EpiLipidomics

CSO Approval Date: 24 March 2020
Start Date: 13 October 2020
End Date: 12 October 2024
EpiLipidNET aims to build and maintain a multidisciplinary pan-European network of researchers, clinicians and enterprises working in the field of lipidomics and epilipidomics to boost a hub of research excellence, advanced knowledge and technology transfer, to promote high level of training for young researchers and facilitate clinical translation.